This weekend's Premier League action gets going early, with a Friday night East Midlands derby, before a huge clash between Arsenal and Liverpool rounds off the action on Sunday.
There are plenty of other key games taking place in-between too so, ahead of all ten fixtures, we bring you 3+ key facts and stats for all ten games.
Leicester City vs Nottingham Forest: Friday 8pm
Forest's most-recent visit to the King Power Stadium saw them smashed 4-0 in October 2022, which represents Leicester's joint-most emphatic victory ever over their neighbours from 25 miles to the north. Overall, the Foxes have won six of their last ten home games against the Garibaldi Reds.
On the road, Nuno Espírito Santo's side remain unbeaten this season, beating Southampton and Liverpool, whilst also drawing at Brighton. and Chelsea Forest haven't avoided defeat in their first five away matches of a top-flight season since 1995.
A win for Steve Cooper's team though would see Leicester claim victory in three successive Premier League matches for the first time since January 2021.
Chris Wood has scored seven of Nottingham Forest's last ten Premier League goals. The New Zealander has bagged six career goals against Leicester, one of his many former employers, only on target against four clubs more frequently: Brighton, Huddersfield, Wolves and West Ham.
Nottingham Forest have conceded only six times so far, their best return eight games into a top-flight campaign since 1980, when they were reigning, back-to-back European champions.
Manchester City vs Southampton: Saturday 3pm
Manchester City have won 12 of their last 16 meetings with Southampton, scoring exactly four in each of these last three victories.
The Saints are winless in 14 visits to the Etihad, losing 13 of them, their most-recent victory there coming in April 2004.
Pep Guardiola's team are currently unbeaten in 51 home matches across all competitions, winning 43 of them, while the Citizens have also won 17 of their last 20 Premier League home games played at 3 o'clock on a Saturday, most-recently defeated in such a fixture by Crystal Palace on 30 October 2021.
Russell Martin's team remain winless this season; the Saints have not failed to win any of their first nine fixtures to start a campaign since 1998, when they did miraculously beat the drop.
Erling Braut Håland has scored in both previous Premier League meetings with Southampton, seeking to end his three-game goal draught in the division.
Aston Villa vs Bournemouth: Saturday 3pm
Aston Villa have won their last two home games against Bournemouth, despite the fact the Cherries had claimed back-to-back victories at Villa Park immediately beforehand, their first-ever victories at the venue.
The Claret and Blue Army have accumulated 17 points after eight games, which represents their best start to a Premier League season since 1998, when Villa went on to finish sixth, winning eight of their first 12 before first tasting defeat back then.
Following loses at Liverpool and Leicester, Andoni Iraola's side are seeking to avoid three successive Premier League defeats away from home without scoring for the first time since February 2023
Brighton & Hove Albion vs Wolverhampton Wanderers: Saturday 3pm
Brighton have won four of their last eight meetings with Wolves, losing only one, including a 3-2 Carabao Cup victory when the pair met in Sussex a mere 38 days ago.
Their last six encounters have produced 22 goals, an average of 3.67 goals per game, despite the fact two of these fixtures featured a combined one goal, very much skewing the date.
Back in April 2023, Brighton smashed Wolverhampton Wanderers 6-0 at the Amex, which remains the Seagulls' record top-flight victory, as well as Wolves' biggest top division defeat since 1968.
With only 1 point on the board after seven games, this is Wolverhampton Wanderers' worst start to a season since 1926; back then, it took Wolves 11 matches to register their first victory, ultimately finishing 15th in the Second Division.
On the flip side, victory for Fabian Hürzeler's team would see the Seagulls claim victory in three successive Premier League wins for the first time in 13 months.
Brentford vs Ipswich Town: Saturday 3pm
Brentford have won each of their last three home games against Ipswich, all coming in the EFL Championship between 2016 and 2019, with this set to be the duo's first-ever top-flight encounter.
This season is the first time in any of Ipswich's 27 top division campaigns that they've failed to claim a win from any of their first eight fixtures.
Bryan Mbeumo has been on target in all four of the Bees' home league games so far this season, despite having not netted at the Brentford Community Stadium since 21 October last year prior to the start of this campaign.
Everton vs Fulham: Saturday 5:30pm
Fulham are unbeaten in six meetings with Everton, winning three of them, despite the fact the Toffees had claimed victory in 12 of their previous 17 encounters; this is the Cottagers' joint-longest undefeated sequence in the history of this fixture, also putting together a six-game sequence between 1926 and 1949 as well as from 1952 to 1960.
Along similar lines, at Goodison, Fulham failed to win any of their 16 visits between 1976 and 2020, losing all 15 in the league, but the Whites have now won each of their last four fixtures on the blue half of Merseyside, including a penalty shootout success in the Carabao Cup last December.
Raúl Jiménez took his tally to five goals for the season last weekend, bagging four in his last five Premier League outings; the Mexican has scored five career goals against Everton, only on target against West Ham more frequently in his entire career.
Chelsea vs Newcastle United: Sunday 2pm
Newcastle have won only one of their last 30 league visits to Stamford Bridge, a run dating back to 1986, that sole victory coming in May 2012, courtesy of Papiss Cissé's breathtaking brace.
Eddie Howe's team travel to West London without a win in four; the Magpies most-recently endured a five-game winless streak in the Premier League in January, which is also when they last suffered back-to-back defeats.
Enzo Maresca's side have scored at least once in 12 successive matches; the Blues last scored in 13 consecutive fixtures in March/April 2022 under Thomas Tuchel (14-game streak).
West Ham United vs Manchester United: Sunday 2pm
Manchester United have lost four of their last six visits to the London Stadium, including both of the last two, meaning West Ham are aiming to collect a third successive home win over the Red Devils for the first time since 1977.
Only two of the last ten encounters between this duo have seen both teams score.
Julen Lopetegui has lost both previous Premier League meetings with Man United, although his Sevilla side did beat them 2-1 in the behind-closed-doors Europa League semi-finals of 2020 in Köln.
Since January 2022, Man United have won only two of 17 Premier League away games in London, losing ten and failing to score in seven of these matches, both of these victories coming at Craven Cottage.
Crystal Palace vs Tottenham Hotspur: Sunday 2pm
Tottenham Hotspur have won each of their last five meetings with Crystal Palace, victorious in 15 of their 18 Premier League encounters since September 2015 overall.
Away from home, the Eagles have lost nine successive league clashes with Spurs, played across three different venues of course, their most-recent win coming in November 1997, when Neil Shipperley was the only scorer.
Oliver Glasner's side are still yet to win this season. This is the first time Palace have failed to win any of their first eight games to start a campaign since 1992, a year Steve Coppell's team were relegated, although victory did come in their nine fixtures back then.
In contrast, victory for Ange Postecoglou's side would see Spurs win five consecutive home games across all competitions for the first time since October 2022 under Antonio Conte.
Arsenal vs Liverpool: Sunday 4:30pm
Victory for Arsenal would see them claim victory in three successive home league games against Liverpool for the first time since 2006.
The 17 Premier League meetings between the pair since the start of 2016 have produced 70 goals, a goal every 22 minutes on average, with both teams scoring in 13 of these fixtures.
By beating RB Leipzig on Wednesday, Liverpool have won each of their first six away games to start a season for the very first time in the club's entire history, while Arne Slot is also the first new manager of any club in English top-flight history to win 11 or more of his first 12 matches in charge.
On the flip side, Mikel Arteta's team have won 35 of their last 45 Premier League home games, losing only four.