Arsenal vs Wolverhampton Wanderers: Saturday 3pm
Wolverhampton Wanderers have won both previous opening day fixtures against Arsenal, prevailing 6-1 in 1946 and 3-1 in 1963.
Arsenal have won only four of their last 12 opening day fixtures, losing five, claiming victory in just three of the last eight played at home, beaten on four occasions.
However, the Gunners have won a total of18 Premier League opening day fixtures, only Manchester United (21) and Chelsea (20) have done so more frequently.
Martin Ødegaard has scored more goals (4) against Wolves than any other opponent in his entire career, on target home and away against them last season.
Gary O'Neil has lost all three managerial meetings with Arsenal while, as a player, he never won any of his five visits to Highbury either.
Newcastle United vs Southampton: Saturday 3pm
Newcastle United have won each of their last five meetings with Southampton, the longest sequence either side has enjoyed since this fixture was first played in 1898, with the Saints victorious in only one of their last 14 encounters.
At St James' Park meantime, Southampton are winless in eight outings, their sole triumph in 20 trips to Tyneside coming nine years ago; Eljero Elia's brace securing victory for Ronald Koeman's team.
The Magpies have won on the opening day at St James' Park in both of the last two seasons, beating Nottingham Forest and Aston Villa, despite failing to do so in six attempts, dating back to 2012, beforehand.
This'll be Southampton's fourth top-flight opening day fixture as a newly-promoted club, yet to win one, drawing with Manchester City in 1966 and Tottenham in 1992, while also beaten by the Sky Blues 3-2 at the Etihad 12 years ago.
Of Alexander Isak' 25 goals last season, 15 were scored at home.